When Is Childhood Kidney Disease Truly Resolved? Perhaps Never

Adolescents with a history of congenital or acquired kidney disorders had a fourfold excess risk for developing end-stage renal disease up to 30 years later.

Once children have recovered from kidney injury and attained normal renal function, normal blood pressure, and normal urinalyses, it has been assumed that end-stage renal disease (ESRD) is unlikely.

In a long-term retrospective study among 1.5 million Israeli conscripts (60% male; mean age, 18 years) with normal serum creatinine values, blood pressure levels, and urinalysis results, researchers found that ESRD developed in just under 2500 individuals after a mean follow-up of 30 years (incidence rate, 5.4 per 100,000). Among some 18,500 with a history of congenital and acquired renal diseases, the risk for ESRD was approximately quadrupled compared with those without a history of any childhood kidney disease. This risk was similarly elevated…

Reviewing Author

F. Bruder Stapleton, MD

Disclosures

Consultant/Advisory BoardCareer Physician

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesAmerican Society of Pediatric Nephrology Foundation (Chair)

F. Bruder Stapleton, MD

Disclosures

Consultant/Advisory BoardCareer Physician

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesAmerican Society of Pediatric Nephrology Foundation (Chair)

When Is Childhood Kidney Disease Truly Resolved? Perhaps Never

Topics

Reviewing Author