More Evidence Supports Acute-Stroke Thrombectomy After Perfusion Studies

DAWN findings are confirmed; patient selection is crucial.

When considering intravenous thrombolysis after stroke, there is a fixed time window of 4.5 hours to intervene. However, improved thrombectomy devices and brain imaging enable some patients to benefit from later intervention, as shown recently in the DAWN trial (NEJM JW Neurol Jan 2018 and N Engl J Med 2018; 378:11).

In the current trial, patients with acute ischemic stroke who could be treated within 6 to 16 hours after onset underwent perfusion imaging. If there was a small infarct core and significantly larger area of brain tissue at-risk (perfusion deficit), the patients were assigned either to medical therapy or to thrombectomy plus medical therapy. Overall, 182 patients (median NIH stroke scale score, 16) were enrolled; the study was h…

Reviewing Author

Seemant Chaturvedi, MD

Disclosures

Consultant/Advisory BoardBayer Pharmaceuticals; Novartis

Grant/Research SupportNational Institute of Neurological Disorders and Stroke

Editorial BoardsNeurology; Stroke

Seemant Chaturvedi, MD

Disclosures

Consultant/Advisory BoardBayer Pharmaceuticals; Novartis

Grant/Research SupportNational Institute of Neurological Disorders and Stroke

Editorial BoardsNeurology; Stroke

More Evidence Supports Acute-Stroke Thrombectomy After Perfusion Studies

Topics

Reviewing Author