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An uncommon association between fluoroquinolones and acute kidney injury has been reported previously (NEJM JW Gen Med Aug 15 2013 and CMAJ 2013; 185:E475). Now, researchers at Mayo Clinic Rochester present a series of 24 cases of biopsy-proven acute interstitial nephritis (AIN) — diagnosed from 1993 through 2016 — that were attributed to recent use of fluoroquinolones (ciprofloxacin or levofloxacin in all but 1 case).
Average duration of fluoroquinolone use was 7 days. Mean baseline serum creatinine was 1.0 mg/dL, and mean peak serum creatinine during AIN episodes was 6.9 mg/dL. Among the 24 patients, 12 had fever, 5 had rash, and 9 had peripheral eosinophilia. Two thirds of patients had pyuria, two thirds had proteinuria, and one third had…