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Response to bacterial infections varies considerably among individuals; variations in bacterial antigenicity, bacterial virulence factors, and the individual immune response all may play a role. To better characterize these factors, researchers compared the acute adaptive T- and B-cell immune responses induced ex vivo by various Staphylococcus aureus and Streptococcus pyogenes strains in lymphocytes isolated from 11 healthy individuals.
Pathogen-specific CD4 T-cell proliferation and interferon-gamma expression showed broad heterogeneity after stimulation with 16 different S. aureus and 3 different S. pyogenes strains, but the relative strength of the response was similar among the donors. Similar heterogeneity was observed in the intensity o…