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To determine which treatments are more likely to prevent medical or psychiatric rehospitalization among patients with bipolar disorder who were prescribed medications by their treating clinicians, researchers studied prospective Finnish databases of 17,877 patients (mean age, 47) who had been hospitalized and discharged for bipolar disorder. During the study period, there were 82,858 rehospitalizations (means per patient, 4.6 hospitalizations for any reason and 2 psychiatric hospitalizations).
In analyses of periods on and off specific treatments within individuals and after appropriate statistical adjustments, lithium had the best track record for reducing the risk for psychiatric rehospitalization (by 33%) and for hospitalization for any r…