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Among breast cancer survivors, risk for a second primary malignancy is greater than risk for a first breast cancer in the general population. To assess how family history might affect risk for contralateral breast cancer (ContraBC), investigators used population-based registries in the U.S., Canada, and Denmark in a case-control study enrolling women with invasive breast cancer diagnosed between 1985 and 2008. Cases were women with a ContraBC diagnosed at least 1 year after the first diagnosis; controls were women with unilateral breast cancer. Participants were genotyped for breast cancer susceptibility single-nucleotide polymorphisms (SNPs) known to be associated with small increases in risk for breast cancer. Many participants were also …