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In people with schizophrenia, tetrahydrocannabinol (THC) has noxious effects on brain structure and function. To extend these findings, investigators examined genetic and activation pathways in neurons derived from human-induced pluripotent stem cells (hiPSCs) from nine people, four with schizophrenia and five controls, with unknown prior THC exposure.
Cells from four controls were exposed to vehicle or THC, with exposure occurring acutely (24 hours) and chronically (7 days). RNA expression in THC-exposed cells differed from vehicle-exposed ones in 497 genes acutely and 810 genes chronically; in 421 of these genes, alterations occurred after both acute and chronic exposure. These differences occurred in glutamate, mitochondrial, synaptic, po…