Exercise Training Doesn't Slow Progression of Cognitive Decline in People with Dementia

Evidence is mixed on whether physical exercise improves cognitive impairment. In this trial, U.K. investigators determined the effects of a moderate-to-high intensity aerobic and strength exercise training program on cognition and other outcomes in 494 people (mean age, 77) with mild-to-moderate dementia.

A total of 329 patients were assigned to an aerobic and strength exercise program, and 165 were assigned to usual care only. The intervention group received 60- to 90-minute, physical therapist–supervised exercise sessions twice weekly for 4 months, followed by prescriptions for unsupervised exercise. Both groups received counseling and advice regarding physical activity. After 12 months, mean scores on a standardized Alzheimer disease cogn…