Supplemental Vitamin D Reduces Wheezing Risk in Black Premature Infants

Supplementing black premature infants' diets with 400 IU/day vitamin D was associated with a 34% reduced risk for recurrent wheezing.

Black premature infants are known to have high rates of postnatal wheezing. To determine the efficacy of vitamin D supplementation in this setting, investigators conducted a randomized, controlled trial involving 300 black infants born at gestational age ≥28 weeks and <37 weeks at four urban hospitals.

Half of the infants were provided 400 IU/day of vitamin D until 6 months' adjusted age and the other half were maintained on dietary sources of vitamin D alone. Prior to randomization, all had received oral vitamin D supplementation in formula or human milk until they were getting 200 IU of vitamin D daily.

At 12 months' adjusted age, 31% of the infants receiving supplemental vitamin D had recurrent wheezing, compared with 42% of those receivin…

Reviewing Author

F. Bruder Stapleton, MD

Disclosures

Consultant/Advisory BoardCareer Physician

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesAmerican Society of Pediatric Nephrology Foundation (Chair)

F. Bruder Stapleton, MD

Disclosures

Consultant/Advisory BoardCareer Physician

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesAmerican Society of Pediatric Nephrology Foundation (Chair)

Supplemental Vitamin D Reduces Wheezing Risk in Black Premature Infants

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Reviewing Author