Prognosis in Myelin Oligodendrocyte Glycoprotein Antibody–Associated Neuromyelitis Optica Spectrum Disorder

Several syndromes have been described with associated myelin oligodendrocyte glycoprotein (MOG) antibodies (Abs). The studies evaluating prognosis in patients with neuromyelitis optica spectrum disorder (NMOSD) with MOG Abs have conflicting findings (NEJM JW Neurol Feb 2018 and Brain 2017 Dec 1; 140:3128).

Investigators identified 197 MOG-Ab-positive patients (median age at presentation, 36; 1:1 sex ratio). Optic neuritis (ON) was the most frequent clinical syndrome (61%), followed by transverse myelitis (TM; 22.3%), combined ON/TM (8%), isolated brainstem syndrome (4%), and encephalopathy (3%). A positive immune profile in the cerebrospinal fluid was not common, present in less than 10%.

Immunosuppressants were used in 54%, which included 67…