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Tools for estimating 10-year cardiovascular disease (CVD) risk were published by the American College of Cardiology and American Heart Association (ACC/AHA) in 2013 (NEJM JW Gen Med Dec 15 2013 and J Am Coll Cardiol 2014; 63:2935). These Pooled Cohort Equations (PCEs) were derived from data from five large population cohorts and were designed to inform guideline-based recommendations for primary-prevention prescribing — including statins, aspirin, and antihypertensives. However, clinician experience and recent publications have suggested that the 2013 PCEs overestimate risk (NEJM JW Gen Med Apr 15 2015 and Ann Intern Med 2015; 162:266).
Investigators used revised statistical methods and only the more modern cohorts to update the PCEs. Among …