A U-shaped association between systolic blood pressure and mortality risk is found in a cohort of people aged >80 in China.
With new blood pressure (BP) guidelines pushing us to treat patients to lower levels, questions are being raised about the prognostic significance of BP in the oldest old. Investigators analyzed data from the Chinese Longitudinal Healthy Longevity Study to assess the association of BP and mortality in a very old cohort (N=4658; mean age, 92; 57% women).
In 3 years of follow-up, 44% of the cohort died. Systolic BP had a U-shaped association with mortality risk. However, adjusted analyses showed no significant association of mortality with diastolic BP, pulse pressure, or mean arterial pressure. The systolic BP with the lowest risk was 129 mm Hg. Increased risks emerged for people with a systolic BP <107 mm Hg or >154 mm Hg. The association pe…
Reviewing Author
DisclosuresConsultant/Advisory BoardUnited Healthcare; Element Science; Eyedentifeye, F-Prime
EquityHugo Health; Refactor Health; Element Science
Grant/Research SupportPfizer; Agency for Healthcare Research and Quality; Janssen Research and Development, National Institute of Biomedical Imaging and Engineering; National Heart, Lung, and Blood Institute; Centers for Disease Control and Prevention; National Cancer Institute; American Heart Association
DisclosuresConsultant/Advisory BoardUnited Healthcare; Element Science; Eyedentifeye, F-Prime
EquityHugo Health; Refactor Health; Element Science
Grant/Research SupportPfizer; Agency for Healthcare Research and Quality; Janssen Research and Development, National Institute of Biomedical Imaging and Engineering; National Heart, Lung, and Blood Institute; Centers for Disease Control and Prevention; National Cancer Institute; American Heart Association