Is Gastric Peroral Endoscopic Myotomy Effective in Refractory Gastroparesis?

In a small prospective trial, all endpoints were improved at 3 months.

Current treatment options for refractory gastroparesis are limited and largely ineffective. Gastric peroral endoscopic myotomy (G-POEM), a recently described endoscopic technique of tunneling under the gastric mucosa and incising the pyloric muscle, has shown promise in retrospective studies.

In a prospective trial of G-POEM for refractory moderate-to-severe gastroparesis, 110 patients were evaluated and 20 were included. Etiologies were diabetes in 10 patients and nondiabetes in the other 10.

The procedure was technically feasible in all patients. Study endpoints were significantly improved at 3 months compared with baseline and included the Gastroparesis Cardinal Symptom Index score (1.3 vs. 3.5), a quality-of-life score, and gastric emptyi…

Reviewing Author

John R. Saltzman, MD

Disclosures

Consultant/Advisory BoardIterative Scopes

Editorial BoardsGastrointestinal Endoscopy; UpToDate

Leadership Positions in Professional SocietiesAmerican College of Gastroenterology (Trustee)

OtherVice President of Medical Affairs, 1Globe Health Institute