Teasing Out the Association Between Premenopausal BMI and Breast Cancer Risk

This inverse relation was strongest among women aged 18 to 24.

Higher body-mass index (BMI) has been associated with lower risk for premenopausal breast cancer but higher risk for postmenopausal breast cancer. To examine this relation in more detail, investigators pooled individual data from cohorts in North America, Europe, Asia, and Australia. Women without breast cancer were recruited from 1963 through 2013, and BMI was categorized according to participants' age (ranges, 18–24, 25–34, 35–44, and 45–54). The primary outcome was invasive or in situ breast cancer diagnosed in premenopausal women.

Among 758,592 women (median age at recruitment, 40.6; median follow-up, 9.3 years), 13,082 breast cancers were diagnosed. Increasing BMI was linearly associated with decreasing risk for breast cancer among all …

Reviewing Author

Andrew M. Kaunitz, MD

Disclosures

RoyaltiesUpToDate

Grant/Research SupportMerck, Mithra, Medicines360

Editorial BoardsContraception; Menopause; Contraceptive Technology Update; OBG Management; Medscape OB/GYN & Women’s Health

Andrew M. Kaunitz, MD

Disclosures

RoyaltiesUpToDate

Grant/Research SupportMerck, Mithra, Medicines360

Editorial BoardsContraception; Menopause; Contraceptive Technology Update; OBG Management; Medscape OB/GYN & Women’s Health

Teasing Out the Association Between Premenopausal BMI and Breast Cancer Risk

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Reviewing Author