More Evidence that Inadvertent HPV Vaccination During Early Pregnancy Is Safe

Aside from immunization for specific indications (e.g., influenza, pertussis), routine vaccination is not recommended during pregnancy; however, women who are unaware they are pregnant might receive vaccines inadvertently. To assess pregnancy outcomes among women who inadvertently received quadrivalent human papillomavirus (HPV) vaccine, investigators examined health records of 2800 women who received at least one dose of the vaccine 16 to 22 weeks before their last menstrual period (LMP), within 6 weeks before the LMP, or during the first 19 weeks of gestation.

Spontaneous abortion occurred in 10.4% of women vaccinated 16 to 22 weeks before the LMP, 11.2% of those vaccinated within 6 weeks before LMP, and 8.5% of those vaccinated during the…