Proven exposure to nicotine on serum testing was associated with greater likelihood of infection with cervical human papillomavirus, including high-risk HPV.
Self-reported smoking has been associated with increased risk for human papillomavirus (HPV) infection as detected with cervical swabs. However, self-reports of smoking are not always accurate. Investigators correlated blood cotinine levels with detection of HPV DNA in self-collected vaginal swabs from 5158 women (age range, 1859) participating in the National Health and Nutrition Examination Survey between 2009 and 2014.
Serum cotinine levels were used to classify women as nonsmokers (57%), those exposed to secondhand smoke (18%), and smokers (25%). Prevalence of high-risk (oncogenic) HPV types was 32% among smokers, 26% in women exposed to secondhand smoke, and 15% among nonsmokers. Overall prevalence of HPV was also higher with nicotine e…
Reviewing Author
DisclosuresConsultant/Advisory BoardAicuris; Bayer; GSK; Innovative Molecules; Merck; MAPP Biopharmaceutical (Safety Monitoring Committee)
RoyaltiesUpToDate
Grant/Research SupportNIH/National Institute of Allergy and Infectious Diseases; GSK; Moderna; Assembly Biomedical; Aicuris
Editorial BoardsSexually Transmitted Diseases; Sexually Transmitted Infections; Journal of Infectious Diseases
Leadership PositionsID Division Chiefs Community of Practice (At-Large Member)
DisclosuresConsultant/Advisory BoardAicuris; Bayer; GSK; Innovative Molecules; Merck; MAPP Biopharmaceutical (Safety Monitoring Committee)
RoyaltiesUpToDate
Grant/Research SupportNIH/National Institute of Allergy and Infectious Diseases; GSK; Moderna; Assembly Biomedical; Aicuris
Editorial BoardsSexually Transmitted Diseases; Sexually Transmitted Infections; Journal of Infectious Diseases
Leadership PositionsID Division Chiefs Community of Practice (At-Large Member)