Birth Year and the Efficacy of Influenza A (H1N1) Vaccination

During the 2015–16 season, vaccination was significantly less effective for those born during 1958–1979 than for those in all other birth cohorts.

In 2009, a distinct strain of influenza — A(H1N1)pdm09 — emerged and subsequently acquired mutations. During the 2015–2016 influenza season, vaccine effectiveness (VE) against the strain was observed to be reduced among patients in some age groups enrolled in the Influenza Vaccine Effectiveness (Flu VE) Network study.

To examine this observation further, investigators at the CDC and several universities analyzed Flu VE data from the 2010–2011 through the 2015–2016 influenza seasons among populations born at different times. The researchers used a test-negative study design to compare the odds of vaccination among cases of influenza A(H1N1)pdm09 versus the odds of vaccination among influenza virus–negative patients.

During the 2015–2016 season…

Reviewing Author

Neil M. Ampel, MD

Disclosures

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesCoccidioidomycosis Study Group (Past President, Secretary, Treasurer)

Neil M. Ampel, MD

Disclosures

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesCoccidioidomycosis Study Group (Past President, Secretary, Treasurer)

Birth Year and the Efficacy of Influenza A (H1N1) Vaccination

Topics

Reviewing Author