A Practical Tool to Predict Progression to Psychotic Disorder

Using information easily obtained in a clinical interview, investigators develop a predictive model with potential for use in the clinic.

Individuals at clinical high risk (CHR) for psychotic disorders have attenuated positive symptoms and a 30% risk for converting to psychotic disorder, usually within 2 years. CHR is defined primarily by the Structured Interview for Psychosis-Risk Syndromes (SIPS), a semistructured interview. An online calculator (NAPLS) to determine risk for conversion requires the SIPS plus neurocognitive testing. To develop a similar prediction model that does not rely on neurocognitive testing, researchers used data on 199 individuals with CHR seeking evaluation (mean age, 20) who were assessed with the SIPS every 3 months for 2 years.

Experienced clinicians established conversion diagnoses; at 2 years, 32% of the sample had converted. Items examined for …

Reviewing Author

Claire Wilcox, MD

Disclosures

EquityMannkind Corporation

Grant/Research SupportNIH

Claire Wilcox, MD

Disclosures

EquityMannkind Corporation

Grant/Research SupportNIH

A Practical Tool to Predict Progression to Psychotic Disorder

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Reviewing Author