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Although magnetic resonance cholangiopancreatography is useful in diagnosing primary sclerosing cholangitis (PSC), current evidence does not support its use as a prognostic tool. With the development of hepatocyte-specific contrast agents such as gadoxetate disodium, the capacity of quantitative magnetic resonance imaging (MRI) to provide prognostic information might be improved.
In a prospective study, researchers examined correlations between gadoxetate-enhanced MRI findings and liver-related indicators and clinical endpoints in 111 patients with PSC (75% men). MRI measured signal intensities in each liver segment, which were used to calculate mean relative enhancement values.
Most participants had moderate-stage disease; the median model f…