Transplantation of HCV-Infected Kidneys into Uninfected Patients

One-year after transplant, all recipients experienced cure of hepatitis C virus infection, good renal function, and good quality of life.

Recent pilot studies demonstrated cure of donor-derived hepatitis C virus (HCV) infection in seronegative recipients of HCV-infected donors (THINKER; N Engl J Med 2017; 376:2394 and Ann Intern Med 2018; 168:533).

Now, investigators provide longer-term (12-month) follow-up data on 10 recipients described in the initial THINKER cohort as well as 6-month follow-up data on 10 additional recipients. The primary outcome was HCV cure. Mental and physical quality of life (QOL) scores were also measured, and a matched case control design was used to assess renal outcomes.

For all 20 recipients, HCV cure was achieved with no relapse. After an initial postoperative decline in QOL, physical QOL scores at later time points exceeded baseline scores, and me…

Reviewing Author

Daniel Kaul, MD

Disclosures

Grant/Research SupportNobelpharma; Pfizer

Leadership Positions in Professional SocietiesAmerican Society of Transplantation (Program Committee)

Daniel Kaul, MD

Disclosures

Grant/Research SupportNobelpharma; Pfizer

Leadership Positions in Professional SocietiesAmerican Society of Transplantation (Program Committee)

Transplantation of HCV-Infected Kidneys into Uninfected Patients

Topics

Reviewing Author