How Common Is Endometrial Cancer in Women with Postmenopausal Bleeding?

A systematic review and meta-analysis suggest 9% of women presenting with this symptom will be found to harbor endometrial malignancy.

Endometrial cancer characteristically presents with postmenopausal bleeding (PMB), yet we still have insufficient data to help counsel women with PMB regarding their likelihood of having this malignancy. Likewise, we lack precise estimates of the proportion of women with endometrial cancer who will present with PMB. To address these issues, investigators performed a systematic review and meta-analysis of 129 studies including 34,432 women with PMB and 6358 with endometrial cancer.

Pooled risk for endometrial cancer among women with PMB was 9% (95% confidence interval, 8%–11%); risk was higher among women not using hormone therapy (HT) than among HT users (12% vs. 7%; P<0.001 for heterogeneity). Prevalence of PMB among women with endometrial …

Reviewing Author

Andrew M. Kaunitz, MD

Disclosures

RoyaltiesUpToDate

Grant/Research SupportMerck, Mithra, Medicines360

Editorial BoardsContraception; Menopause; Contraceptive Technology Update; OBG Management; Medscape OB/GYN & Women’s Health

Andrew M. Kaunitz, MD

Disclosures

RoyaltiesUpToDate

Grant/Research SupportMerck, Mithra, Medicines360

Editorial BoardsContraception; Menopause; Contraceptive Technology Update; OBG Management; Medscape OB/GYN & Women’s Health

How Common Is Endometrial Cancer in Women with Postmenopausal Bleeding?

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Reviewing Author