Compared with conventional troponin testing, high sensitivity troponin I testing identifies more patients with ACS but is not associated with improved outcomes.
Conventional troponin testing can miss some patients with acute coronary syndrome (ACS), especially single tests performed early in the disease course. Use of high-sensitivity troponin I (hsTnI) testing can reduce missed cases but may decrease specificity. These authors evaluated whether use of an hsTnI assay affected the combined outcome of subsequent myocardial infarction or death at 1 year in nearly 48,300 patients with suspected ACS at 10 hospitals in Scotland. Patients underwent simultaneous conventional and hsTnI testing; hsTnI results were concealed from treating physicians for approximately 19,000 patients in a cluster-randomized, stepped-wedge fashion.
Using a sex-specific threshold for hsTnI > the 99th centile of the normal populat…
Reviewing Author
DisclosuresRoyaltiesUpToDate
Grant/Research SupportEunice Kennedy Shriver National Institute of Child Health and Human Development; MINDSOURCE
Editorial BoardsThe Quarterly Update: Reviews of Current Child Abuse Medical Research; Child Abuse & Neglect: The International Journal
Leadership Positions in Professional SocietiesThe Helfer Society (Executive Committee Member)
DisclosuresRoyaltiesUpToDate
Grant/Research SupportEunice Kennedy Shriver National Institute of Child Health and Human Development; MINDSOURCE
Editorial BoardsThe Quarterly Update: Reviews of Current Child Abuse Medical Research; Child Abuse & Neglect: The International Journal
Leadership Positions in Professional SocietiesThe Helfer Society (Executive Committee Member)