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As noted in a recent summary of treatment for major depressive disorder (NEJM JW Psychiatry Apr 2018 and Biol Psychiatry 2018 Feb 15; [e-pub]), coordination between neural networks is involved in directing cognitive resources to external stimuli and reducing the impact of internally generated states. In a new study, researchers sought to shed light on the importance of balance between the salience network (SN), the central executive network (CEN), and the default mode network (DMN) in distinguishing between internally and externally generated information.
The researchers used resting functional MRI to identify dynamic time-varying cross-network interactions in 35 schizophrenia patients and 35 controls (mean age, 35). After adjustment for con…