With electrical stimulation and intensive training, patients had improvements in function.
In a partially manufacturer-supported trial, four patients with chronic motor paralysis after traumatic spinal cord injury underwent epidural stimulation and intense rehabilitation in standing and stepping. Treatment with stimulation began at least 2 years after their injury. All four patients had complete paralysis from trauma in the cervical or thoracic regions. Intensive physical therapy alone, 10 hours per week for up to 9 weeks, did not result in motor movement, confirmed by electromyography.
A 16-electrode array was implanted epidurally over L1 to S1-2 and was set to activate lower extremity muscles. Several weeks after implantation, different muscles groups were activated by stimulating each epidural anode and cathode to determine com…
Reviewing Author
DisclosuresConsultant/Advisory BoardAlexion Pharmaceuticals; Amgen; Astoria; Biogen; Bristol Myers Squibb; Celltrion; Genentech; Hoffmann-La Roche; Genzyme; EMD Serono; Immpact-Bio; Immunic Therapeutics; Kyverna; Lundbeck; Novartis; Sandoz; TG Therapeutics
Grant/Research SupportNational Institutes of Health; National Multiple Sclerosis Society; U.S. Department of Defense
Leadership Positions in Professional SocietiesConsortium of Multiple Sclerosis Centers (Treasurer)
DisclosuresConsultant/Advisory BoardAlexion Pharmaceuticals; Amgen; Astoria; Biogen; Bristol Myers Squibb; Celltrion; Genentech; Hoffmann-La Roche; Genzyme; EMD Serono; Immpact-Bio; Immunic Therapeutics; Kyverna; Lundbeck; Novartis; Sandoz; TG Therapeutics
Grant/Research SupportNational Institutes of Health; National Multiple Sclerosis Society; U.S. Department of Defense
Leadership Positions in Professional SocietiesConsortium of Multiple Sclerosis Centers (Treasurer)