Elevated Lipoprotein(a) Levels Are Associated with Increased Cardiovascular Events …

… irrespective of whether patients are on statin therapy.

Elevated lipoprotein(a) [Lp(a)] levels have been identified as a risk factor for cardiovascular disease (CVD) in general populations. To see whether Lp(a) levels are also associated with events in patients with established CVD or on statin therapy, researchers performed a manufacturer-funded meta-analysis of patient-level data from 29,069 patients (mean age, 62; 28% women) from seven randomized, placebo-controlled statin trials.

During 95,576 person-years of follow-up, 5751 events occurred. As expected, statin therapy significantly lowered LDL levels; however, it was not associated with significant changes in Lp(a) levels. Hazard ratios (HRs) for cardiovascular events (fatal or nonfatal coronary heart disease, stroke, or revascularization pr…

Reviewing Author

Karol E. Watson, MD, PhD, FACC

Disclosures

Consultant/Advisory BoardBoehringer Ingelheim; Amgen; Novartis; Lilly; Amarin

Speaker’s BureauBoehringer Ingelheim

Grant/Research SupportNIH

Editorial BoardsCirculation (Associate Editor)