Relation Between Oral Anticoagulant Type and Functional Outcomes, Mortality in Stroke

Outcomes were similar with vitamin-K antagonists and non–vitamin-K antagonists; however, admission symptoms were less severe and baseline hematoma volume was lower with non–vitamin-K antagonists.

Compared to warfarin, non–vitamin-K-antagonist oral anticoagulants (NOACs) have similar efficacy for ischemic stroke prevention in patients with nonvalvular atrial fibrillation but lower incidence of intracerebral hemorrhage (ICH). Whether radiographic and clinical outcomes for ICHs that do occur with NOACs are different from those that occur with vitamin-K antagonists (VKAs) such as warfarin is unclear. Researchers conducted a systematic review of studies comparing outcomes of these anticoagulation-related hemorrhages and performed an individual patient-level meta-analysis of data on 219 NOAC-associated ICHs and 831 VKA-associated ICHs from seven studies.

In the primary analysis, NOAC- and VKA-associated ICHs were associated with similar al…

Reviewing Author

Anthony S. Kim, MD

Disclosures

Grant/Research SupportNIH/National Institute of Neurological Disorders and Stroke; NIH/National Center for Advancing Translational Sciences

Anthony S. Kim, MD

Disclosures

Grant/Research SupportNIH/National Institute of Neurological Disorders and Stroke; NIH/National Center for Advancing Translational Sciences

Relation Between Oral Anticoagulant Type and Functional Outcomes, Mortality in Stroke

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Reviewing Author