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In multiple sclerosis, fingolimod decreases egress of lymphocytes from the spleen and lymph nodes. In stroke, it has also been reported to decrease microvascular thrombus formation and improve postischemic reperfusion.
This preliminary study, conducted at three Chinese centers, assessed the potential value of combined administration of fingolimod with alteplase. Some 46 patients with acute ischemic stroke who could be treated within a 4.5- to 6.0-hour time window were recruited. All patients had a proximal large-artery occlusion (carotid or middle cerebral artery) plus documented impaired blood flow. The primary study endpoints were change in the NIH stroke scale (NIHSS) score at 24 hours and functional status at 90 days.
Patients received ei…