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The standard endoscopic treatment of high-risk peptic ulcers is epinephrine injection followed by bipolar cautery or hemoclips. Despite the popularity of hemoclips, initial bleeding control is not achieved in 5% to 20% of patients, and rebleeding occurs in 10% to 20%. A possible alternative is monopolar hemostatic forceps with soft coagulation (MHFSC), a technique widely used to control bleeding in patients undergoing endoscopic submucosal dissection (ESD), which has recently been applied to treating bleeding peptic ulcers.
MHFSC was compared with hemoclips for efficacy of achieving initial hemostasis in a randomized trial involving 112 patients with peptic ulcers and high-risk stigmata of recent hemorrhage (Forrest class 1a, 1b, or 2a). All…