Rates of Hepatitis B Seroclearance Among Patients with Chronic Infection

HBV clearance rates are low regardless of therapy receipt, and being seropositive for hepatitis B e antigen slows that even further.

Current hepatitis B virus (HBV) therapy is effective at viral suppression but not viral clearance. Reported rates of spontaneous and treatment-induced viral clearance vary in the current literature. This systematic review and meta-analysis attempts a more precise estimate.

Reviewers searched databases to identify studies that reported hepatitis B surface antigen (HBsAg) seroclearance in HBV-infected patients who were followed for at least 1 year and had at least one HBsAg testing performed during follow-up. Cumulative HBsAg seroclearance incidence was determined at 5, 10, and 15 years using a random-effects model.

Thirty-four articles were included in the meta-analysis, comprising 42,588 patients; 22 of the 34 studies were felt to be at low r…

Reviewing Author

Atif Zaman, MD, MPH

Disclosures

Nothing to disclose

Atif Zaman, MD, MPH

Disclosures

Nothing to disclose

Rates of Hepatitis B Seroclearance Among Patients with Chronic Infection

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Reviewing Author