Evaluation of Prophylactic Cefazolin Pharmacokinetics in Cardiac Surgery

Two surgical factors affected risk for postsurgery infections in a retrospective analysis.

Sternal wound infections after cardiac surgery pose considerable morbidity and mortality risks. Although surgical antibiotic prophylaxis (SAP) markedly reduces these risks, the most relevant pharmacokinetic parameters driving infection prevention by SAP are unknown.

To identify the most important parameters affecting infection risk in patients undergoing cardiac surgery and receiving cefazolin SAP, researchers measured total and free cefazolin concentrations in blood samples taken 30 minutes after the preoperative dose, before intraoperative redosing, and within 15 minutes of wound closure. Patients were monitored for surgical site infection (SSI) for 30 days after surgery. Multivariate logistic regression analysis (including relevant clinic…

Reviewing Author

George Sakoulas, MD

Disclosures

Consultant/Advisory BoardParatek Pharmaceuticals; Nestle Corp.; AbbVie; Shionogi

Speaker’s BureauAllergan/AbbVie; Paratek Pharmaceuticals; Nestle Corp.

RoyaltiesUpToDate

Editorial BoardsAntimicrobial Agents and Chemotherapy; Open Forum Infectious Diseases