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For over 20 years, fine-needle aspiration (FNA) devices were the standard instruments for tissue acquisition during endoscopic ultrasound. Recently, fine-needle biopsy (FNB) devices, which provide tissue cores, have become commercially available. Most studies comparing the efficacy of FNA and FNB are retrospective, and each needle type and size has its advocates.
In an international, prospective, randomized study, investigators compared the efficacy of a 25-gauge FNA device and a 20-gauge FNB device for sampling solid lesions in over 600 patients. Pancreatic masses accounted for just over half of the target lesions sampled. Technical success was achieved in essentially all patients regardless of the needle used (100% with FNA and 99% with FN…