A New Method to Estimate Glomerular Filtration Rate in Patients with Liver Disease

Renal failure is a predictor of mortality in patients with liver disease. Current methods of estimating renal function in patients with liver disease are inaccurate, such as Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) and Modification of Diet in Renal Disease (MDRD-4, MDRD-6). Now, a new estimation model called Glomerular Filtration Rate (GFR) Assessment In Liver disease (GRAIL), has been developed and evaluated.

In a multicenter cohort study, researchers analyzed over 12,000 GFR measurements taken using iothalamate clearance in over 3000 patients at liver transplantation listing and after transplantation (1 month, 3 months, 1 year, and then annually for 25 years). Estimated GFR was calculated using GRAIL, which is based on v…