Lymphopenia and Risk for Infection and Infection-Related Death

In a population-based prospective study, lymphopenia was significantly associated with increased risk for infection and infection-related death during 6 years of follow-up.

Neutropenia (neutrophil count <500/µL) is known to carry increased risk for infection, as is a T-helper-cell count <250/µL in HIV-positive individuals. What about lymphopenia in general?

To study the association between lymphopenia and risks for infection and infection-related death, researchers used data from the prospective Copenhagen General Population Study involving 98,344 individuals (mean age, 58; 45% male) of the general Danish population who were examined between November 2003 and July 2013 and had blood lymphocyte counts available. During a median follow-up of 6 years, 8.5% of the study participants developed infections, and 1.1% died from infection.

Multivariate analysis adjusted for age, sex, smoking, alcohol intake, body-mass ind…

Reviewing Author

Thomas Glück, MD

Disclosures

Editorial BoardsConsilium Infectiorum by InfectoPharm, Infection

Thomas Glück, MD

Disclosures

Editorial BoardsConsilium Infectiorum by InfectoPharm, Infection

Lymphopenia and Risk for Infection and Infection-Related Death

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Reviewing Author