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Sciatica is a disabling condition characterized by radiating posterior or posterolateral leg pain that is sometimes accompanied by back pain, sensory loss, weakness, or reflex abnormalities. Evidence regarding medical treatment is limited. Both gabapentin and pregabalin have been widely used to treat neuropathic pain including sciatica. The efficacy for sciatica and side effects of both medications have not been firmly established.
In this randomized, double-blind, double-dummy, cross-over trial of pregabalin versus gabapentin for management of chronic sciatica (CS), 20 patients with unilateral CS were randomized to receive gabapentin (400 mg to 800 mg, 3 times daily) then pregabalin (150 mg to 300 mg twice daily, plus once-daily placebo for…