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Many people who lose weight intentionally struggle to maintain their lower weight. In the carbohydrate-insulin model of obesity, a high glycemic load increases the blood insulin-to-glucagon ratio, which results in increased hunger, lower energy expenditure, and weight gain. To test this model, researchers examined the effects on total-energy (kcal/day) expenditure of three diets with different carbohydrate-to-fat ratios.
Researchers randomized 164 adults (body-mass index, ≥25 kg/m2) to high-, moderate-, or low-carbohydrate diets (60%, 40%, and 20% carbohydrates, respectively) with inverse proportions of fat (20%, 40%, and 60% fats, respectively). Diets had a fixed amount of protein (20%), and total energy intakes to maintain weight loss. Aft…