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Several randomized trials have shown that aspirin helps prevent colorectal cancer (CRC), but uncertainties remain about dosing and target populations. Preliminary evidence also suggests that the omega-3 fatty acid eicosapentaenoic acid (EPA) might help prevent CRC. To examine the effects of aspirin and EPA on CRC precursors — colorectal adenomas — U.K. researchers performed this placebo-controlled, randomized trial. About 700 patients (age range, 55–73) at high risk for CRC (i.e., multiple adenomas on baseline standardized screening colonoscopy) received aspirin (300 mg daily), EPA (1 g twice daily), both, or neither for 12 months. Participants underwent repeat colonoscopy at the end of the trial.
The primary outcome, proportion of patients …