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Cognitive-behavioral therapy (CBT) — a skills-based psychotherapy targeting maladaptive information processing and behaviors seen in brain-gut disorders — has been shown to improve symptoms in patients with irritable bowel syndrome (IBS), but the durability of the benefit is unknown.
Investigators conducted a secondary analysis of a randomized, controlled trial of CBT in 436 patients (80% women) with at least moderately severe, treatment-refractory IBS. Patients were randomized to one of three 10-week interventions: 4 sessions of home-based CBT, 10 sessions of clinic-based CBT, or 4 sessions of IBS education (without CBT). Treatment response was measured with validated IBS symptom assessment instruments at 2 weeks and 3, 6, 9, and 12 months …