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Dear Readers,
The NEJM Journal Watch Infectious Diseases editorial board was challenged this year in selecting the top 10 most important articles; instead, we provide our top 11 choices. The board thought that the most important study this year documented the arrival of ceftriaxone-resistant Neisseria gonorrhoeae in North America. Additional important studies included two that addressed management of latent tuberculosis and two important studies on HIV treatment, as well as individual studies on the efficacy of high-dose influenza vaccine, the first of a new class of agents for influenza, a major study on the utility of oral antibiotic therapy for endocarditis, a comparative study of meropenem and piperacillin-tazobactam efficacies, and a re…