Neurofilament Light Protein Levels — Another Marker for Neurodegeneration?

Neurofilament light protein levels were associated with a plethora of neurodegenerative conditions.

Neurofilament light (NFL) protein in cerebrospinal fluid (CSF) is a marker for axonal damage. In this case-control, single-center study, researchers examined whether NFL levels in the CSF are associated with neurodegeneration and disease progression.

The 913 participants included 75 healthy control patients. Diagnoses in the neurodegenerative group included mild cognitive impairment (MCI), Alzheimer disease (AD), amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and parkinsonian syndromes such as Parkinson disease (PD), dementia with Lewy bodies (DLB), corticobasal syndrome (CBS), and progressive supranuclear palsy (PSP). Cognitive performance was measured with the Mini-Mental State Examination (MMSE). In the neurodegenerat…

Reviewing Author

Jennifer Rose V. Molano, MD

Disclosures

Grant/Research SupportNational Center for Advancing Translational Science – Cincinnati Center for Clinical and Translational Science and Training

Editorial BoardsBrain & Life

Jennifer Rose V. Molano, MD

Disclosures

Grant/Research SupportNational Center for Advancing Translational Science – Cincinnati Center for Clinical and Translational Science and Training

Editorial BoardsBrain & Life

Neurofilament Light Protein Levels — Another Marker for Neurodegeneration?

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Reviewing Author