Does Prophylactic Salpingo-Oophorectomy Also Reduce Risk for Breast Cancer?

Although earlier reports suggested that risk-reducing salpingo-oophorectomy (RRSO) in BRCA1 and BRCA2 mutation carriers also lowered risk for breast cancer, a more recent Dutch study using time-dependent analysis (which defined women as unexposed prior to RRSO and exposed following RRSO) found that RRSO did not reduce risk for breast cancer (J Natl Cancer Inst 2015; 107:djv033). Now, in a prospective cohort study, investigators followed 17,917 women (age at baseline, 18–79; 7.2% with BRCA1 or BRCA2 mutations) without known breast cancer at baseline for a median of 10.7 years, during which 1046 received diagnoses of incident breast cancer.

Taking the time exposed to RRSO into consideration, no association between RRSO and risk for breast canc…