The risk for community-acquired pneumonia is increased in both persons living with HIV and those without HIV who use prescription opioids, especially high-dose or immunosuppressive opioids.
As the opioid epidemic continues, it has become clear that opioid use is associated with infectious complications not typically considered secondary to opioid use disorder. Studies have documented an increase in pneumococcal disease associated with opioid prescription (NEJM JW Infect Dis Apr 2018 and Ann Intern Med 2018; 168:396). In this nested case-controlled study, investigators at Veterans Affairs medical centers explored the relationship of opioid prescription, dosage, and type with risk for community-acquired pneumonia (CAP) in people living with HIV (PLWH) or without HIV infection.
A total of 21,146 controls (8710 HIV uninfected and 12,436 PLWH) and 4246 CAP cases (1776 HIV uninfected and 2470 PLWH) were included. The sample was 98.9%…
Reviewing Author
DisclosuresGrant/Research SupportNIH/National Institute of Allergy and Infectious Diseases; NIH/National Institute on Drug Abuse
Editorial BoardsJAIDS: Journal of Acquired Immune Deficiency Syndromes; Vaccines
Leadership Positions in Professional SocietiesInternational Antiviral Society–USA (Board of Directors); Infectious Diseases Society of America (Past President)
DisclosuresGrant/Research SupportNIH/National Institute of Allergy and Infectious Diseases; NIH/National Institute on Drug Abuse
Editorial BoardsJAIDS: Journal of Acquired Immune Deficiency Syndromes; Vaccines
Leadership Positions in Professional SocietiesInternational Antiviral Society–USA (Board of Directors); Infectious Diseases Society of America (Past President)