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Endoscopic ultrasonography–guided fine-needle aspiration (EUS-FNA) has been a standard tool to biopsy and evaluate solid pancreatic lesions for more than 20 years. However, there is debate among practitioners regarding the value of EUS-FNA for very small lesions. The consensus is that the diagnostic yield from sampling very small lesions is low and needs to be balanced with the risks of the biopsy procedure itself, most notably bleeding and pancreatitis.
To evaluate the yield of EUS-FNA of solid pancreatic lesions of various sizes, investigators in Japan conducted an 8.5-year retrospective cohort study involving 761 patients (mean age, 65.7 years) with 788 lesions. Needle gauge was decided at the discretion of the endoscopist. Lesions were s…