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Treatment for ongoing mild-to-moderate ulcerative colitis in the face of active therapy remains problematic. Fecal microbiota transplantation (FMT) has been suggested as a safe alternative to more-aggressive immunosuppression for controlling inflammation.
In the current trial, researchers at three Australian centers randomized 73 patients with mild-to-moderate ulcerative colitis to undergo FMT with pooled donor stool processed in anaerobic conditions or autologous stool processed in standard fashion. FMT was administered via colonoscopy followed by two enemas within 7 days.
The primary endpoint of steroid-free remission at week 8 was met by 32% of the pooled donor stool group versus 9% of the autologous stool group (odds ratio, 5.0, 95% confi…