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Adverse pregnancy outcomes (most notably preeclampsia) are associated with abnormalities of maternal renal function. Although it's well known that the elevated glomerular filtration rate associated with pregnancy results in lower serum creatinine levels, the exact time-course of this change has not been elucidated. Investigators in Ontario conducted a population-based investigation of >300,000 serum creatinine measurements from 10 weeks preconception to 18 weeks postpartum in >240,000 singleton pregnancies.
Mean serum creatinine prior to pregnancy was 60 µmol/L (0.68 g/dL). Levels quickly descended to a nadir of 47 µmol/L (0.53 g/dL) between 16 and 32 weeks' gestation, after which a steady increase toward prepregnancy levels began and was re…