Anxiety in particular contributes additive detrimental effects.
Multiple sclerosis (MS) is associated with depression and cognitive deficits. The cognitive problems are assumed to be related to brain pathology, but the role of anxiety and depression is unclear. These investigators assessed the relationship between anxiety and depression and cognitive impairment in patients with MS and other immune-mediated disorders (IMDs) that do not directly affect the central nervous system.
Study participants were 255 patients with MS, 247 patients with inflammatory bowel disease, 154 with rheumatoid arthritis, and 308 patients with DSM-IV anxiety and depressive disorders but no IMD. Evaluation included structured psychiatric interviews, measures of anxiety and depression severity, and assessments of cognition.
Across…
Reviewing Author
DisclosuresRoyaltiesTextbook of Traumatic Brain Injury, 2nd and 3rd editions
Editorial BoardsUpToDate; Journal of Neuropsychiatry and Clinical Neuroscience
Leadership Positions in Professional SocietiesNorth American Brain Injury Association (Board Member); National Institute on Disability, Independent Living, and Rehabilitation Research (Chair of Data Monitoring Safety Board for study of donepezil on cognition after traumatic brain injury)
DisclosuresRoyaltiesTextbook of Traumatic Brain Injury, 2nd and 3rd editions
Editorial BoardsUpToDate; Journal of Neuropsychiatry and Clinical Neuroscience
Leadership Positions in Professional SocietiesNorth American Brain Injury Association (Board Member); National Institute on Disability, Independent Living, and Rehabilitation Research (Chair of Data Monitoring Safety Board for study of donepezil on cognition after traumatic brain injury)