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Hereditary germline mutations in DNA repair genes are associated with excess risk for developing prostate cancer. Prior studies have shown that 8% to 12% of men with metastatic prostate cancer have such mutations, the most common of which are BRCA2, CHEK2, ATM, and BRCA1.
To further evaluate the impact of germline mutations (BRCA1/2, ATM, and PALB2) on metastatic castration-resistant prostate cancer (mCRPC), investigators in Spain conducted a 3-year, prospective, multicenter, cohort study involving 419 patients (98% white; median age, 66.2 years) with histologically confirmed prostate cancer. Of these, 202 (48%) had metastatic disease, 96 (23%) reported a family history of prostate cancer, and 26 (6.2%) had a germline mutation in BRCA2 (14),…