Loading...
The search for neural correlates of negative symptoms in schizophrenia (e.g., expressive deficits, anhedonia) has been frustratingly inconclusive. In this two-site study, investigators used whole-brain functional MRI (fMRI) of 44 patients (66% men) with early-course schizophrenia (80%) or schizoaffective disorder (20%) to empirically identify brain networks correlated with negative symptoms. After correction for age, sex, site, and medication dosage, analyses showed negative symptom severity to be most strongly associated with poor connectivity between the right dorsolateral prefrontal cortex and the midline cerebellar node associated with the default network.
Since repetitive transcranial magnetic stimulation (rTMS) has previously been show…