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To test noninferiority of the novel aminoglycoside antibiotic plazomicin to meropenem in treating complicated urinary tract infection (UTI), researchers conducted a manufacturer-sponsored study. They blindly randomized 601 patients to receive plazomicin (15 mg/Kg intravenously once daily) or meropenem (1g IV every 8 hours) for a total of 10 days, including an option to step down to oral antibiotic after at least 4 days of study drug. The primary study endpoints were composite cure (clinical cure and microbiologic eradication) at day 5 and at test of cure (TOC; 15–19 days after start of treatment) among patients who were randomized, received at least one dose of study drug, and had a cultured pathogen susceptible to meropenem and plazomicin.…