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Dye-based chromoendoscopy increases the detection of colorectal neoplasia at colonoscopy but has not gained widespread use in average-risk patients because it is cumbersome and time-consuming. An orally administered dye formulation with colon-release properties could overcome these disadvantages.
In this industry-funded, multicenter trial, investigators randomized 1250 patients to take oral methylene blue-multimatrix (MB-MMX) or placebo during bowel preparation for routine colonoscopy. The results were as follows:
The adenoma detection rate (ADR) was significantly higher in the MB-MMX group compared with the placebo group (56% vs. 48%).
Detection of sessile serrated polyp or traditional serrated adenoma was significantly higher in the MB-MMX g…