Itching to Be Delivered at 36 Weeks' Gestation

For women with intrahepatic cholestasis of pregnancy, risk for stillbirth was significantly increased when serum bile acids concentration was ≥100 µmol/L.

Women with intrahepatic cholestasis of pregnancy (ICP) have pruritus (often debilitating), elevated serum bile acids, and excess risk for stillbirth. To better characterize the relation between serum bile acids concentration and stillbirth risk, investigators in the U.K. performed a meta-analysis including >5000 women with ICP.

Serum bile acids concentration was more highly predictive of stillbirth than alanine aminotransferase, aspartate aminotransferase, or total bilirubin. In a sensitivity analysis, a serum bile acids concentration of ≥100 µmol/L was associated with a statistically significant 3.4% prevalence in stillbirth; concentrations of 40 to 99 µmol/L were associated with a prevalence of 0.3% that was not statistically significantly…

Reviewing Author

Robert L. Barbieri, MD

Disclosures

Grant/Research SupportNational Institutes of Health

Editorial BoardsUpToDate

Robert L. Barbieri, MD

Disclosures

Grant/Research SupportNational Institutes of Health

Editorial BoardsUpToDate

Itching to Be Delivered at 36 Weeks' Gestation

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Reviewing Author